Donations and History

How has research over the years improved life with Polyposis?

1990s - today:

• studies of the effects of non steroidal anti inflammatory drugs (NSAIDs) on the polyps in the rectum and duodenum in FAP have led to the use of Celecoxib for the treatment of advanced duodenal and rectal polyposis.
• review of the patients in the study of duodenal polyposis 10 years previously has led to use of a staging system so that screening intervals can be varied.
• studies of the genetics of desmoid tumours are slowly increasing our understanding of this problem.
• first studies into gene therapy.
• studies have taken place to try to identify genes that modify the severity of FAP.
• the genes causing Peutz Jeghers syndrome have been identified and genetic testing is now available on the NHS for most families.

This is just a very brief overview of all the research that has been done since 1924. In the last twenty five years alone there have been more than eighty papers printed in medical journals as a result of research done in the St Mark’s Hospital Polyposis Registry.

We hope that you will agree that without continued contributions from people like yourself, these advancements would have been delayed for generations.

Please contribute what you can - every donation helps.

The Polyposis Registry is funded by voluntary contributions - please support us by donating here.

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